profhasem.blogg.se - Best form of magnesium for low t

Philadelphia: Wolters Kluwer Health, Lippincott Williams & Wilkins c2014. Brunner & Suddarth's Handbook of Laboratory and Diagnostic Tests. Learn more about laboratory tests, reference ranges, and understanding results. If you have questions about your results, talk to your health care provider. If your results show you have too much magnesium, your provider may recommend IV therapies (medicine delivered directly to your veins) that can remove excess magnesium. If your results show you have a magnesium deficiency, your health care provider will probably recommend you take magnesium supplements to raise levels of the mineral.

Overuse of antacids or laxatives that contain magnesium.

Diabetic ketoacidosis, a life-threatening complication of diabetes.

Dehydration, the loss of too much bodily fluids.

Addison disease, a disorder of the adrenal glands.

If your results show you have a higher than normal amount of magnesium, it may be a sign of:

Digestive disorder, such as Crohn's disease or ulcerative colitis.

Until more is known about the potential benefits and risks, it may be best not to use magnesium orotate.If your results show you have a magnesium deficiency, it may be a sign of: Magnesium orotate is not the best choice as a magnesium supplement and despite preliminary evidence of a benefit for people with heart disease, there is also evidence suggesting a potential safety concern at around the high dosage used for that purpose. Based on these data, a panel of the European Food Safety Authority (EFSA) concluded that orotic acid-containing products, such as magnesium orotate, represent a safety concern when used in amounts of 100 mg/kg or more daily (e.g., 7,000 mg for a 70 kg adult) ( EFSA Journal 2009). Lower doses of 50 mg/kg/day did not have this effect ( Laconi, Carcinogenesis 1993, Laconi, Carcinogenesis 1993, Laconi, Carcinogenesis 1988). Some concerns about the safety of orotic acid from supplements such as magnesium orotate have been raised. Research in animals shows that doses of 100 mg/kg/day or more of orotic acid have tumor promoting effects in experimental tumors. Preliminary research in animals and humans suggests that this protective role of magnesium orotate may relate to its involvement in the synthesis of genetic material such as RNA and DNA ( Rosenfeldt, Cardiovasc Drugs Ther 1998).Īlthough magnesium orotate is often promoted and used to improve athletic performance or endurance, there is no reliable evidence that it works for this purpose. It also improved heart failure symptoms in about 40% of patients ( Stepura, Int J Cardiol 2009).

Magnesium orotate might have a protective role in heart disease. A preliminary clinical study in people with heart failure found that giving 6,000 mg of magnesium orotate daily for one month, followed by 3,000 mg daily for 11 months reduced the risk of dying during the study by about 25%. In contrast, you can get the same amount of magnesium for as little as 2 cents, as shown in 's Magnesium Supplements Review. To get, for example, 200 mg of magnesium from magnesium orotate supplements you might spend 10 to 18 cents. In fact, magnesium orotate probably isn't the best choice as a magnesium supplement for preventing or treating magnesium deficiency because it doesn't appear to offer an advantage over others and it can cost up to 9 times more than other magnesium products. However, research does not show that minerals (such as magnesium or zinc) bound to orotic acid have improved absorption ( Andermann, Eur J Drug Metab Pharmacokinet 1982). As a magnesium supplement, it is often promoted as a better source of magnesium than other forms (e.g., magnesium oxide) due to improved absorption. Some websites claim that orotate carries magnesium across cell membranes and produces higher levels of magnesium within the cells.